100 Peso

Front: Domingos Ramos (1935–1966), Guinea-Bissau nationalist leader and independence fighter who served as a military commander in the PAIGC (African Party for the Independence of Guinea and Cape Verde) during the independence war against Portuguese colonial rule. He died in combat and is honored as a national hero. The note features his portrait at right, with traditional textile patterns, the national coat of arms showing a black star above a flaming torch and shell, a carved wooden statue, and a stylized palm motif.

Back: The Banco Central da Guiné-Bissau building in Bissau, the headquarters of the nation's central bank. The modernist multi-story structure is shown in architectural elevation with decorative serpent motifs and traditional patterns flanking the building. The design reflects the post-independence nation-building era and the establishment of independent monetary institutions.